The overarching goal of the Rutgers Discovery Informatics Institute (RDI²), New Jersey’s Center for Advanced Computation, is to establish a comprehensive and internationally competitive Computational and Data-Enabled Science and Engineering (CDS&E) effort at Rutgers University that can nurture the fundamental integration of research, education, and infrastructure. This integration will stimulate new thinking and new practices in CDS&E that will be catalyzed by cyberinfrastructure advances. Collectively, these efforts will address today’s grand challenges in science, engineering, and industry.