The increasing abundance of empirical data captured from the real world and perceptual data captured from virtual reality lets us devise novel approaches for data-driven computational design. In this talk, I will discuss the recent progress of my team in devising computational design approaches for automatically generating human-centered designs, including interior design, architectural layout design, zoomorphic furniture design, fashion design and the design of reconfigurable objects and dissection puzzles. I will also talk about how human perceptual data tracked from virtual reality can be employed for creating novel applications such as personalized exergaming and training. Finally, I will share insights from the graphics, vision and robotics perspectives on enhancing computers as creativity support tools, and on the possible future roles of humans and AI in design.